Disodium clodronate tetrahydrate

Research use only, not for human use.

Clodronic acid(INN) orclodronate disodium(USAN) is a first generation (non-nitrogenous)?bisphosphonate.

Clodronic acid(INN) orclodronate disodium(USAN) is a first generation (non-nitrogenous) bisphosphonate. It is an anti-osteoporotic drug approved for the prevention and treatment of osteoporosis in post-menopausal women and men to reduce vertebral fractures,hyperparathyroidism,hypercalcemia in malignancy,multiple myeloma and fracture related pain because of its potent anti-inflammatory and analgesic effects shown as a reduction in inflammatory markers like IL-1β,IL-6, and TNF-alfa.(In Vitro):Clodronate disodium tetrahydrate, a first-generation bisphosphonate, significantly attenuates neuropathic and inflammatory pain unrelated to bone abnormalities via inhibition of VNUT, a key molecule for the initiation of purinergic chemical transmission .Clodronate disodium tetrahydrate is an allosteric modulator of VNUT Cl- dependence .Clodronate disodium tetrahydrate acts as antiresorptive in osteoporosis.(In Vivo):Clodronate disodium tetrahydrate (10 mg/kg; i.v.) attenuates inflammatory pain via VNUT inhibition.Clodronate disodium tetrahydrate attenuates inflammation via VNUT inhibition .

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Animal Model:C57BL/6 mice (22-30 g) Dosage:10 mg/kg Administration:Intravenous injection Result:Attenuated carrageenan- or complete Freund’s adjuvant (CFA)-evoked inflammatory pain.

Clodronic acid

Apoptosis

IL Receptor

IL-1β| IL-6| TNF-α

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88416-50-6

360.92

CH10Cl2Na2O10P2

>98% (HPLC)

Soluble in Water

C(P(=O)(O)[O-])(P(=O)(O)[O-])(Cl)Cl.O.O.O.O.[Na+].[Na+]

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(-20℃)

With Ice Pack

≥ 2 years